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Apamea (Greek: Απάμεια, Apameia; Arabic: آفاميا‎, Afamia), on the right bank of the Orontes River, was a treasure city and stud-depot of the Seleucid kings, and was the capital of Apamene. (Stephanus of Byzantium s. v.; Strabo xvi. p. 752; Ptolemy v. 15. § 19; Festus Avienus, v. 1083; Anton. Itin.; Hierocles). Its site is found about 55 km (34 mi) to the northwest of Hama, Syria, overlooking the Ghab valley. Previously known as Pharmake, it was fortified and enlarged by Seleucus I Nicator in 300 BC, who so named it after his Bactrian wife, Apama – not his mother, as Stephanus asserts (compare Strabo, p. 578). In pursuance of his policy of Hellenizing Syria, it bore the Macedonian name of Pella. The fortress was placed upon a hill; the windings of the Orontes, with the lake and marshes, gave it a peninsular form, whence its other name of Cherronêsos. Seleucus had his commissariat there, 500 elephants, with 30,000 mares, and 300 stallions. The pretender, Diodotus Tryphon, made Apamea the basis of his operations. (Strab. l. c.) Located at a strategic crossroads for Eastern commerce, the city flourished to the extent that its population eventually numbered half a million. It was one of the four cities of the Syrian tetrapolis.